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Patient Zero may refer to:
- Patient Zero (Campaign) - The bonus campaign for HITMAN™.
- Patient Zero (Mission) - The mission of the same name, for said campaign.
- Owen Cage - The primary target of said mission, a cult member that intentionally infected himself with a deadly, contagious virus with the intent to become patient zero.
- Patient Zero (Elusive Target) - A cut elusive target mission.
- Owen Cage (Elusive Target) - The target of said mission, bio-terrorist that intentionally infected himself with a deadly, contagious virus with the intent to become patient zero.
- Patient Zero (Mission) - The mission of the same name, for said campaign.