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Icon-Mission

Patient Zero is the fourth, final and titular mission of the Patient Zero bonus campaign, featured in HITMAN™ - Game of the Year Edition.


Targets[]

Icon-Target
Eliminate Owen Cage
Icon-Target
Eliminate Klaus Liebleid
Icon-Target
Eliminate all infected (if virus spreads)


Objectives[]

Icon-Objective
Get the vaccine (if infected)


Exfiltrate[]

Icon-Exit
Locate the exit

Patient Zero[]

Agent 47's private jet speeds through a turbulent, stormy night sky.

Diana Burnwood (VO): "Good work in Colorado, 47. I hope you've managed to get some sleep on your trans-pacific flight."

Inside, 47 reviews various weapons and tools of the trade.

Agent 47: "I'm fine."

Diana (VO): "As always...Well, as you've guessed, you're en route to Japan. We've intercepted a memo indicating that local authorities have detained a man suspected of carrying an infectious disease and shipped him off to a medical facility further north."

A map of Japan and the GAMA facility appear, as well as the Liberation cult insignia.

Agent 47 (VO): "Another cult operative?"

Diana (VO): "That has been confirmed, yes, but even better--we believe this man is the one responsible for the development of the virus itself. His last known whereabouts match the final set of coordinates sent by Nabazov's dead man's trigger. It appears he was headed for Sydney, Australia, but his arrest put a stop to that."

Agent 47: "That was...fortunate."

Diana (VO): "Luck has little to do with it."

Security footage of the man sitting cross-legged in a lounge area appear. His disease-ridden face and HAZMAT-clad operatives on a plane also appear.

Diana (CONT'D): "Passengers noticed him performing some sort of religious ritual in the airport lounge and got nervous. Police detained him for further questioning when he started showing signs of illness. Standard protocols kicked in and he's now en route to Hokkaido."

The jet speeds ahead in the lightning storm.

Diana (VO): "The mission briefing will be available for review in a few moments."

Diana (VO): "You have two targets. First, Owen Cage, the rogue viral researcher responsible for the weaponization of the Nabazov virus. Cage was moved to the Hokkaido GAMA facility by Japanese authorities. All evidence indicates that he infected himself, intending to become Patient Zero.

He is currently being kept alive in isolation by your second target, Klaus Liebleid. An Ether Corporation scientist, Dr. Liebleid is trying to extract as much information about the virus as possible before Owen Cage dies.

We cannot allow Ether to succeed in reverse engineering the virus, and profiting from it. Your task is simple, 47. Contain the virus by eliminating Cage and Liebleid. Whatever happens, the Nabazov virus must be destroyed. We must contain it here, no matter the cost.

I'll leave you to prepare."

MISSION ACTIVE
― Mission Briefing


Description[]

With the Nabazov Virus safely contained in Colorado, 47 must now end the threat of the virus for good by eliminating the man responsible for its creation, rogue viral researcher Owen Cage.

Intending to become the virus' 'Patient Zero', Cage deliberately infected himself with the virus, and was attempting to spread it in Sydney, Australia. Luckily, before he could travel he was detained by authorities and sent to be quarantined at the GAMA hospital in Hokkaido. There, researchers from the Ether Biotech Corporation have been able to create a vaccine. But the lead researcher, Klaus Liebleid, has been keeping Cage alive for study, likely attempting to reverse engineer the virus for Ether's use.

47 must infiltrate the hospital and eliminate Cage and Liebleid, as well as any people within the building infected with the virus. All while avoiding becoming infected himself.

Despite being isolated, the Nabazov virus will begin spreading from Owen Cage to other people present in the mission if the player does not intervene. The virus can potentially spread to every NPC within the mission area; anyone not wearing a Bio Suit can be infected given they come in close enough contact to an infected NPC. All those infected with the virus become additional targets.

47 can also become infected with the virus. If the player makes direct contact with Owen Cage or another infected NPC without wearing either the Bio Suit or Head Researcher disguise, 47 will become infected and the player must locate and use the virus' vaccine before leaving the mission. If five minutes pass before the vaccine is used, 47 will die and the mission will fail.

Mission Stories[]

There are no Mission Stories available for this mission.

Intelligence[]

  • A Weaponized Virus
The following information may contain spoilers.

These notes show the doctor's exploration of the weaponised virus' infection rates and lethality. He believes it to be intended to attack built up areas such as cities, while leaving sparsely populated areas relatively unaffected. He seems to admire the craftmanship.

  • Examination Schedule
The following information may contain spoilers.

Patient Zero is to be brought for examination in the theatre at regular intervals. Ensure full biohazard protocols are followed at all times when in close proximity.

  • Necrotic Die-Off
The following information may contain spoilers.

These notes indicate that the virus dies off rapidly as soon as the host-body dies. Essentially, eliminating someone will immediately end the risk of infection.

  • Note
The following information may contain spoilers.

"I think I have a guardian angel. Is it you Rebecka? I somehow survived my attempts to take my own life and I feel it is not without reason. I see now that the work of the cult was evil. I hope someone will stop it. In case I get infected, I brought something that will surely end my life. I will carry it around with me, just to be sure. /Jeff"

  • Safe Key
The following information may contain spoilers.

Key to a safe.

  • The Antidote
The following information may contain spoilers.

Head researcher Klaus Leibleid has developed an antidote for his private use. It's stored with the Stem Cell supplies near the Hospital furnace room.

Challenges[]

There are 18 challenges in total: 8 "Assassination", 6 "Feats" & 4 "The Classics", worth 46000XP and contain 1 unlock.

Type Key: A=Assasssination; F=Feats; TC=The Classics
Name Type Description Rewards
Needle Work
Needle Work
A
Icon-Assassination
Assassinate Owen Cage with a lethal injection disguised as Klaus Liebleid in the main surgery room. +2000XP
Inferno
Inferno
A
Icon-Assassination
Assassinate Klaus Liebleid and Owen Cage using the incineration procedure without any other casualties. +2000XP
Piano Man
Piano Man H3
A
Icon-Assassination
Assassinate a target with the fiber wire in Hokkaido. +1000XP
Versatile Assassin
Versatile H3
A
Icon-Assassination
Complete all the Versatile challenges in Hokkaido:
  • Piano Man
  • Someone Could Hurt Themselves
  • Hold My Hair
  • Straight Shot
  • Tasteless, Traceless
+4000XP
Tasteless, Traceless
Tasteless H3
A
Icon-Assassination
Assassinate a target with lethal poison in Hokkaido. +1000XP
Hold My Hair
Drown H3
A
Icon-Assassination
Assassinate a target by drowning them in Hokkaido. +1000XP
Someone Could Hurt Themselves
Accident H3
A
Icon-Assassination
Assassinate a target in an accident in Hokkaido. +1000XP
Straight Shot
Headshot H3
A
Icon-Assassination
Assassinate a target with a headshot in Hokkaido. +1000XP
Patient 47*
Patient 47
F
Icon-Disguise
  • Become infected by the virus.
  • Lie down on a morgue table while infected.
  • Complete the mission.
Subject 47 Suit - Carpathian Mountains
  • +2000XP
No Rubber
No Rubber
F
Icon-Disguise
Complete the mission without using a Hazmat Suit. +2000XP
You Know the Number
You Know the Number
F
Icon-Disguise
[REDACTED]
  • Kill at least 47 people infected with the Nabazov Virus besides Owen Cage.
  • Complete the mission.
+4000XP
Lucky Shot
Lucky Shot
F
Icon-Disguise
  • Become infected by the virus.
  • Inject the vaccine with 10 seconds or less remaining until 47's death.
+1000XP
Containment
Containment
F
Icon-Disguise
Complete the mission without any additional infected. +4000XP
Chameleon
Chameleon H3
F
Icon-Discovery
Find and equip all disguises in Hokkaido. +4000XP
Suit Only
SuitOnly2021
TC
Icon-Classic
  • Assassinate the targets and complete the mission.
  • Do it all in your suit.
+4000XP
Silent Assassin
SilentAssassin2021
TC
Icon-Classic
  • Complete "Patient Zero".
  • Only eliminate the targets.
  • No bodies found.
  • Do not get spotted.
  • If you are detected by cameras, erase or destroy the evidence.
+4000XP
Sniper Assassin
Sniper Assassin Tile H3
TC
Icon-Classic
  • Complete "Patient Zero".
  • Assassinate your targets with a sniper rifle.
  • Only eliminate the targets.
  • Do not get spotted.
+4000XP
Silent Assassin, Suit Only
SASO 2021
TC
Icon-Classic
  • Complete "Patient Zero".
  • Only eliminate the targets.
  • No bodies found.
  • Do not get spotted.
  • If you are detected by cameras, erase or destroy the evidence.
  • Do it all in your suit.
+4000XP

*Added in HITMAN™ III Patch 3.160.

Cut Challenges[]

Name Type Description Rewards
No Evidence (cut in HITMAN™ III)
No Evidence S2
TC
Icon-Classic
  • Complete "Patient Zero" with no bodies discovered.
  • If you are detected by cameras, erase or destroy the evidence.
+1000XP

Mastery[]

Mastery Level Type Unlock Description
1 Starting Location
Icon-Start Location
Infiltrating Below the Helipad
Infiltrating Below the Helipad No Suit
47 infiltrates the hospital facility by ascending the steep mountainside, and enters right below the helipad [Wearing Recon Gear disguise in HITMAN™ & HITMAN™ 2; suit restriction removed in HITMAN™ III Patch 3.150].
Agency Pickup
Icon-Smuggled Item
Garage
Hokkaido SI5
The ICA can smuggle a large secure case into the hospital's garage space.

Disguises[]

Items[]

Firearms
Bartoli 75R
Bartoli 75R HITMAN2021
Striker
Striker HITMAN2021
HX-7
HX-7 HITMAN2021
Tactical Bartoli 12G
Tactical Bartoli 12G HITMAN2021
Melee
Baseball Bat
Baseball Bat HITMAN2021
Bust
Statue Bust A HITMAN2021
Cleaver
Cleaver HITMAN2021
Cowboy Bust
Cowboy Bust HITMAN2021
Crowbar
Crowbar HITMAN2021
Fire Axe
Fire Axe HITMAN2021
Fire Poker
Fire Poker HITMAN2021
Frying Pan
Frying Pan HITMAN2021
Hammer
Hammer HITMAN2021
Katana
Katana HITMAN2021
Kitchen Knife
Kitchen Knife HITMAN2021
Lead Pipe
Lead Pipe HITMAN2021
Police Baton
Police Baton HITMAN2021
Scalpel
Scalpel HITMAN2021
Scissors
Scissors HITMAN2021
Screwdriver
Screwdriver HITMAN2021
Shovel
Shovel HITMAN2021
Soda Can
DrPopp Soda
Wrench
Wrench HITMAN2021
Explosives Containers Poisons
Fire Extinguisher
Fire Extinguisher HITMAN2021
Propane Flask
Propane Flask HITMAN2021
Leather Briefcase*
Leather Briefcase HITMAN2021
Botulinum Toxin
Botulinum Toxin HITMAN2021
Fugu Fish Poison
Fugu Fish Poison HITMAN2021
Emetic Rat Poison
Emetic Rat Poison
Modern Lethal Syringe
Modern Lethal Syringe HITMAN2021
Distractions Tools
Coin
Coin-HITMAN2021
Disposable Scrambler
Disposable Scrambler HITMAN2021

*HITMAN™ 2 & HITMAN™ III only.

Gallery[]

Mission Map[]

HITMAPS Wordmark

The full interactive map for this mission can be viewed via HITMAPS by clicking the image or clicking here.

Trivia[]

  • This mission potentially has the most targets in the entire Hitman franchise at 141 if all NPCs get infected by the virus.
  • Without any interference from 47, the first person to get infected by the virus will usually be a female surgeon who leaves the second floor and stands by the entrance to the operating theatre. After catching the virus from Cage, she will then pass by a bodyguard, who proceeds to go on a smoke break around the garage. He will then spread it onto Nails, who then spreads it around the staff canteen. After a period of time, a female doctor will head from the second floor to the waiting area for a cup of coffee, potentially catching the virus from Cage and spreading it onto the second floor.
  • Wearing any quarantine facility disguises will not give access to the resort and spa areas of GAMA.
  • There is a NPC called Kokoro that is found standing on a platform out-of-bounds, that will die if you shoot the heart. He is likely a test NPC, as "kokoro" is a Japanese word for "heart".
  • In the resort lounge, a patient will rant to a staff member about Amos Dexter's smoking habits. He will then jokingly suggest changing his last name to Dexter, citing "the one from South Dakota". This is a reference to Blake Dexter, the main antagonist of Hitman: Absolution, and the fan theory that both are related.
  • The VIP Patient outfit can be found in the bathroom of the room 47 stays in during Situs Inversus. However, wearing it will make the entire map hostile, much like the Recon Gear.
  • Regular poison injection on Cage will register as foul play instead of an accident kill; if the body is found, Silent Assassin is forfeit.
  • In HITMAN™ III, the Contracts mode version of the mission removes the Nabazov Virus mechanic. Additionally, the Recon Gear is no longer automatically assigned, and now any suit can be used.
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