The Scalpel is a melee weapon that appears in Hitman 2: Silent Assassin, and HITMAN™. The animations for the scalpel are the same as the other knifes in the game. In the Hitman 2: Silent Assassin, it is named the Surgeon's Scalpel.
- Terminal Hospitality - In several rooms in the basement. Can be used to fake a real operation and kill Deewana Ji.
- Situs Inversus - In the morgue. Appears as a lethal weapon.
- Patient Zero (Mission) - In the Hall behind the surgery room, At a table.