The Sedative Syringe (known simply as Syringe) is a syringe which contains a type of anesthetic that can render a person unconscious when poisoned.


The sedative syringe contains enough anesthetic to knock a grown man unconscious for a considerable amount of time, and thus acts as a non-lethal weapon. It can be used for close-quarters take-downs. In earlier Hitman games, it is a disposable weapon - you use it once, and then it is gone.

However, in Absolution, the syringe may also be used as a lethal weapon. The syringe can be injected head-on, pacifying the victim, or it could be thrown into the victim's head, killing them. Alternatively, it may be thrown and used as a distraction.


Hitman: Contracts

  • The player has one in their inventory at the start of each mission.
  • Asylum Aftermath - some can be found in one of the surgical rooms (near where a mental patient is butchering a 48 corpse with a kitchen knife) and there's one in 2nd floor next to the elevator.
  • Hunter and Hunted - there is one in the 2nd floor room with the dead civilian in (with the hip hop stereo playing and the policeman guarding outside).

Hitman: Blood Money

Hitman: Absolution

  • Rosewood: On the table in the medical lab on the top floor and first floor.
  • Death Factory: On a crate in the bottom floor of R&D.


  • This weapon can be used on sleeping characters, making them unable to get up but stay alive.
  • The sedative syringe is the non-lethal counterpart of the Poison Syringe.
  • In the Contracts mission Asylum Aftermath and the Blood Money mission Flatline, the Stun Gun is available and has a similar effect as the sedative, and has no limit of uses. Unfortunately, it can't be brought to other missions.
  • In Blood Money, it's possible to use a handgun or one-handed SMG to grab someone from behind (known as Human shield in game) and knock them out if nobody else is too close by to save sedative doses.
  • This and Poison Syringe will alert the NPCs, make sure you only equip and use it when there is no witness around.
  • You can reduce the "injection time" by sprinting before you inject your target, if that fails, keep sprinting will help.
  • Before Blood Money, the sedative syringes only knocked out NPCs temporarily, but in Blood Money the sedation lasts the whole level or until someone finds and wakes up the NPC.
  • In Absolution, when a target is injected with the syringe in Contracts mode, it is presumed that they are overdosed, as it registers as a kill. It can also serves as a lethal weapon in both single and multiplayer, able to be jammed into a target's throat and torn sideways, or thrown into a target's head.